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Table 3 Results for cytotoxicity (C) models

From: Structure-activity models of oral clearance, cytotoxicity, and LD50: a screen for promising anticancer compounds

Model Cell Line Task set Kernel Average test set precision, (+) labels Average test set precision, (-) labels
C.1 H460 LC50 Gaussian 0.707 (0.032) 0.809 (0.008)
C.2 H460 LC50 & TGI Gaussian LC50: 0.711 (0.034) TGI: 0.732 (0.021) LC50: 0.809 (0.009) TGI: 0.834 (0.009)
C.3 H460 TGI Gaussian 0.729 (0.028) 0.838 (0.009)
C.4 H460 LC50 linear 0.630 (0.056)* 0.788 (0.014)*
C.5 H460 TGI linear 0.683 (0.047)** 0.803 (0.013)**
C.6 MCF7 LC50 Gaussian 0.675 (0.019) 0.801 (0.011)
C.7 MCF7 LC50 & TGI Gaussian LC50: 0.674 (0.036) TGI: 0.685 (0.027) LC50: 0.798 (0.016) TGI: 0.820 (0.012)
C.8 SF-268 LC50 & TGI Gaussian LC50: 0.665 (0.056) TGI: 0.698 (0.047) LC50: 0.826 (0.014) TGI: 0.845 (0.013)
  1. * Significant differences by ANOVA (p < 0.05): C.4 vs. C.1 and C.2
  2. ** Significant differences by ANOVA (p < 0.05): C.5 vs. C.2 and C.3