From: Pharmacological Properties of DOV 315,090, an ocinaplon metabolite
Receptor Type | α1β2γ2S | α1β2γ3 | α2β2γ2S | α2β2γ3 | α3β2γ2S | α5β2γ2S | α5β2γ3 | |
---|---|---|---|---|---|---|---|---|
diazepam (DZ) | IC50 (μM) | 0.03 | 0.22 | 0.04 | 0.21 | 0.05 | 0.03 | 0.09 |
 | pIC50 | 7.54 ± 0.09 | 6.67 ± 0.08 | 7.50 ± 0.10 | 6.80 ± 0.26 | 7.32 ± 0.08 | 7.57 ± 0.13 | 7.09 ± 0.13 |
ocinaplon (OC) | IC50 (μM) | 6.3 | 2.3 | 24 | 20 | 7.7 | 9.6 | 10 |
 | pIC50 | 5.20 ± 0.14 | 5.65 ± 0.01 | 4.62 ± 0.14 | 4.74 ± 0.15 | 5.12 ± 0.06 | 5.02 ± 0.03 | 5.01 ± 0.18 |
 | IC50/DZ IC50 | 218 | 10.5 | 759 | 115 | 158 | 355 | 120 |
DOV 315,090 | IC50 (μM) | 7.0 | 5.5 | 24 | 20 | 9.3 | 22 | 27 |
 | pIC50 | 5.19 ± 0.12 | 5.27 ± 0.07 | 4.63 ± 0.05 | 4.72 ± 0.09 | 5.08 ± 0.14 | 4.67 ± 0.08 | 4.58 ± 0.09 |
 | IC50/DZ IC50 | 220 | 25 | 760 | 120 | 170 | 790 | 323 |
 | IC50/OC IC50 | 1.02 | 2.40 | 0.89 | 0.98 | 1.09 | 2.24 | 2.59 |