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Figure 6 | BMC Pharmacology

Figure 6

From: Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

Figure 6

Effect of thiamine and benfotiamine on the total thiamine content in thiamine-depleted Neuro 2a cells. The cells were grown for 8 days in thiamine deficient DMEM medium containing 5% fetal calf serum, before addition of thiamine (1 μM, ○) or benfotiamine (1 μM, ●) and intracellular thiamine derivatives were determined at the times indicated. The data (mean ± SEM, n = 3) were analyzed by two-way ANOVA followed by the Bonferroni post-test for comparison of the benfotiamine and the thiamine groups at different times (*, p < 0.05).

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BMC Pharmacology

ISSN: 1471-2210