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Figure 4 | BMC Pharmacology

Figure 4

From: Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

Figure 4

Contents of thiamine, ThMP, ThDP and total thiamine in the liver and the brain of mice (strain sv129) after daily oral administration of 200 mM HP-β-CD (8 animals) or benfotiamine (100 mg/kg) in approximately 100 μl of a 200 HP-β-CD solution (10 animals) for 14 days. The data (mean ± SEM) were analyzed by MANOVA (Liver : Wilk's Lambda = 0.24, p = 0.0061; Brain : Wilk's Lambda = 0.779, p = 0.48) followed by an ANOVA for each thiamine compound (*, p < 0.05; **, p < 0.01).

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BMC Pharmacology

ISSN: 1471-2210