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Figure 2 | BMC Pharmacology

Figure 2

From: Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives

Figure 2

Contents of thiamine, ThMP, ThDP and total thiamine in the blood, the liver and the brain of mice (strain sv129) 1 hour after a single oral administration of 100 μl of 200 mM HP-b-CD or benfotiamine (100 mg/kg) in approximately 100 μl of a 200 mM HP-b-CD solution. The data were analyzed by MANOVA (Wilk's Lambda, p = 0.0002, 0.0145 and 0.27 for blood, liver and brain respectively) followed by ANOVA for each thiamine compound (*, p < 0.05; **, p < 0.01). The results are expressed as mean ± SEM for 4 animals in each group.

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BMC Pharmacology

ISSN: 1471-2210