Skip to main content
Figure 3 | BMC Pharmacology

Figure 3

From: Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25–35)-induced amnesia

Figure 3

Effects of CS on spontaneous locomotor activity in middle-aged mice. Spontaneous locomotor activity in mice was evaluated in the open field test on the day as indicated in the experimental schedule (Figure 2). YNG, young adult mice (i.p. saline for 7 days); MID, middle-aged mice (i.p. saline for 7 days, control); CS1, CS10, and CS25, middle-aged mice treated i.p. for 7 days with CS in doses of 1, 10, or 25 mg/kg respectively. Each group comprised a minimum of eight mice. Columns represent the means ± SEM of locomotor activity counts during a 3-min observation period. *P < 0.05 vs. MID. †P < 0.05 vs. YNG.

Back to article page

BMC Pharmacology

ISSN: 1471-2210