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Table 2 24-h urinary chloride (Cl-) excretion data and K+/Cl- ratio in male and female control and NaVPA-rat groups (mean ± SD)

From: Sodium valproate stimulates potassium and chloride urinary excretion in rats: gender differences

Rat groups

n

24-h Cl- level (mmol/l)

24-h Cl- excretion (mmol/24 h)

24-h Cl- excretion per 100 g body weight (mmol/100 g)

Cl-/creatinine ratio

K+/Cl- ratio

Control rats

      

females

14

104 ± 51

0.886 ± 0.40

0.371 ± 0.15

12.6 ± 6.9

1.30 ± 0.44

males

14

168 ± 128

1.164 ± 0.70

0.420 ± 0.26

14.2 ± 8.8

1.15 ± 0.54

NaVPA-rats

      

females

13

180 ± 60•

1.997 ± 0.52• *

0.833 ± 0.22• *

24.6 ± 4.7• *

0.49 ± 0.12•

males

13

275 ± 184•

3.396 ± 1.21• *

1.208 ± 0.53• *

34.6 ± 16.5• *

0.45 ± 0.22•

  1. • – Statistically significant difference, as compared to control group (p < 0.05).
  2. * – Statistically significant difference versus the other gender (p < 0.05).