BMC Pharmacology

Table 1 Potency and selectivity of caspase-3 inhibitors.

From: Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO

	K_i^app ^a (nM)
Inhibitor	Caspase-3	Caspase-7	Caspase-8	Caspase-9
Ac-DEVD-CHO	0.288 ± 0.087	4.48 ± 0.21	0.597 ± 0.095	1.35 ± 0.31
Ac-DQTD-CHO	1.27 ± 0.11	21.8 ± 1.1	9.75 ± 1.09	14.5 ± 0.7
Ac-DMQD-CHO	13.3 ± 0.3	>200	>200	>200
Ac-DNLD-CHO	0.680 ± 0.163	55.7 ± 6.0	>200	>200

^a K_i^app was calculated from the IC₅₀ value, K_i^app = IC₅₀/(1+ [S]/K_m), where K_m is the Michaelis constant of the substrate and [S] is the substrate concentration in the assay.

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