Skip to main content

Table 1 Potency and selectivity of caspase-3 inhibitors.

From: Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO

  Kiapp a (nM)
Inhibitor Caspase-3 Caspase-7 Caspase-8 Caspase-9
Ac-DEVD-CHO 0.288 ± 0.087 4.48 ± 0.21 0.597 ± 0.095 1.35 ± 0.31
Ac-DQTD-CHO 1.27 ± 0.11 21.8 ± 1.1 9.75 ± 1.09 14.5 ± 0.7
Ac-DMQD-CHO 13.3 ± 0.3 >200 >200 >200
Ac-DNLD-CHO 0.680 ± 0.163 55.7 ± 6.0 >200 >200
  1. a Kiapp was calculated from the IC50 value, Kiapp = IC50/(1+ [S]/Km), where Km is the Michaelis constant of the substrate and [S] is the substrate concentration in the assay.