Figure 8
From: Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO
Comparison of the binding modes of Ac-DNLD-CHO, Ac-DEVD-CHO, Ac-DQTD-CHO, and Ac-DMQD-CHO with caspases-3, -7, -8, and -9. Nitrogen, oxygen, and carbon atoms of the inhibitors are illustrated in blue, red, and green, respectively. Hydrogen bonds with the S3 subsite are shown as blue circles and dashed lines. Hydrophobic interactions with the S2 subsite are shown as red circles.