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Table 2 Concentrations of ciclesonide and des-CIC in rabbit nasal mucosa.

From: Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa

Time, min Ciclesonide pmol/g tissue * p value ** des-CIC pmol/g tissue * p value **
Hypotonic suspension     
30 5884 ± 3982 NS 575 ± 276.3 < 0.05
120 2835 ± 2118 NS 366 ± 207 < 0.05
240 212.5 ± 102.1 < 0.05 215.2 ± 112.2 < 0.05
Isotonic suspension     
30 232.3 ± 46.3 - 102 ± 32.1 -
120 83 ± 69.1 - 32 ± 25 -
240 13.3 ± 16.4 - 16 ± 20.3 -
  1. des-CIC = desisobutyryl-ciclesonide; NS = not significant.
  2. * = Data are mean ± standard deviation.
  3. ** = Versus isotonic suspension.