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Table 2 Concentrations of ciclesonide and des-CIC in rabbit nasal mucosa.

From: Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa

Time, min

Ciclesonide pmol/g tissue *

p value **

des-CIC pmol/g tissue *

p value **

Hypotonic suspension

    

30

5884 ± 3982

NS

575 ± 276.3

< 0.05

120

2835 ± 2118

NS

366 ± 207

< 0.05

240

212.5 ± 102.1

< 0.05

215.2 ± 112.2

< 0.05

Isotonic suspension

    

30

232.3 ± 46.3

-

102 ± 32.1

-

120

83 ± 69.1

-

32 ± 25

-

240

13.3 ± 16.4

-

16 ± 20.3

-

  1. des-CIC = desisobutyryl-ciclesonide; NS = not significant.
  2. * = Data are mean ± standard deviation.
  3. ** = Versus isotonic suspension.
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BMC Pharmacology

ISSN: 1471-2210