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Table 2 Relative mRNA concentrations and activities of antioxidant enzymes and concentrations of some antioxidants in the liver of pigs fed a control diet or a diet supplemented with 5 g clofibrate per kg for 28 days

From: Clofibrate treatment in pigs: Effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents

Treatment

Control (n = 9)

Clofibrate (n = 9)

Catalase

  

   mRNA concentration

1.00 ± 0.49

1.72 ± 0.58*

   Activity (U/mg protein)

0.75 ± 0.14

1.06 ± 0.16*

Glutathione peroxidase

  

   mRNA concentration

1.00 ± 0.17

0.74 ± 0.18*

   Activity (U/mg protein)

4.7 ± 0.8

4.0 ± 0.4*

Glutathione S-transferase

  

   mRNA concentration

1.00 ± 0.41

0.90 ± 0.32

   Activity (U/mg protein)

0.76 ± 0.26

0.76 ± 0.18

Superoxide dismutase

  

   mRNA concentration

1.00 ± 0.42

1.77 ± 0.40*

   Activity (U/mg protein)

43 ± 8

97 ± 13*

Glutathione, total (nmol/mg protein)

2.13 ± 0.51

1.97 ± 0.90

Glutathione, reduced (nmol/mg protein)

1.70 ± 0.50

1.67 ± 1.02

α-tocopherol

  

   (nmol/g)

14.5 ± 2.5

8.7 ± 2.9*

   [nmol/(mmol triglycerides + cholesterol)]

2.32 ± 0.40

1.36 ± 0.45*

  1. Results are means ± SD.
  2. *Significantly different from control group (P < 0.05)
  3. #Relative to control (= 1.00)