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Figure 5 | BMC Pharmacology

Figure 5

From: The enantiomers of tramadol and its major metabolite inhibit peristalsis in the guinea pig small intestine via differential mechanisms

Figure 5

Naloxone (Nalox) attenuates the inhibitory effect of tramadol on peristalsis. The increase in PPT due to 100 μM (-)-tramadol, (+)-tramadol and O-desmethyltramadol was significantly reduced by pre-treatment with the pan-opioid receptor antagonist naloxone (0.5 μM). The bars represent means with SEM, n = 6 segments, *P < 0.05 as compared with vehicle (Tyrode's solution).

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