Figure 4

Behavioural responses to propofol and etomidate in β3(N265M) and wild type mice on pure C57/Bl6J or 129X1/SvJ background. A, C. Reduction in the duration of the loss of righting reflex (LORR) induced by etomidate and propofol in A) C57/Bl6J β3(N265M) and C) 129X1/SvJ β3(N265M) mice is not influenced by the genetic background. B, D. Failure to induce loss of hindlimb withdrawal reflex induced by propofol and etomidate in B) C57/Bl6J β3(N265M) and D) 129X1/SvJ β3(N265M) mice is not influenced by the genetic background. n = 10. * p < 0.05, *** p < 0.001.