Table 2 Pharmacokinetic parameters of Etoposide (VP16) administered alone or in combination
From: Impact of imatinib on the pharmacokinetics and in vivo efficacy of etoposide and/or ifosfamide
Etoposide | Etoposide + fluconazole | Etoposide + imatinib | Etoposide + fluconazole + imatinib | |
|---|---|---|---|---|
T 1/2 (hours) | 0.24 | 0.23 | 0.35 | 0.49 |
AUC (μg/L × h) | 19970 | 23680 | 38380 | 48960 |
Clearance (ml/h) | 0.62 | 0.51 | 0.32 | 0.25 |