Figure 3
From: Impact of imatinib on the pharmacokinetics and in vivo efficacy of etoposide and/or ifosfamide
Fecal and urine excretion of etoposide in CD1 mice. Etoposide (VP16) levels were determined in feces (ng of etoposide/g of feces) when mice were treated with etoposide alone (A, B) or in combination with imatinib (B) or in combination with imatinib and fluconazole (B). Etoposide (VP16) levels were determined in urine (ng of etoposide/24 hours of urine) when mice were treated with etoposide alone (C, D) or in combination with imatinib (C) or in combination with imatinib and fluconazole (D).