Figure 2
From: Impact of imatinib on the pharmacokinetics and in vivo efficacy of etoposide and/or ifosfamide
(A) Mean AUC 0–3 h of etoposide (VP16) in CD1 mice. Area Under Curve concentration versus time of etoposide (VP16) was calculated between base time (0) and 3 hours after administration of etoposide alone or etoposide plus fluconazole or etoposide plus imatinib or etoposide with imatinib and fluconazole. (B) Concentration-time curve of etoposide (VP16) administered with STI571. After administration of etoposide (VP16) with STI571, concentrations of VP16 peaked at 30.9 ± 2.1 ng/mL, followed by a bi-exponential decline. (C) Graphical analysis between calculated concentrations and observed concentrations of etoposide (VP16).