An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome data

Table 4 Two promising candidates for drug-targetable PPIs

	bait	prey	bait	prey
protein name	RXRA	NRIP1	CDK2	CDKN1A
full length of amino acid sequence	462	1158	298	191
N terminus of fragment	212	641	5	1
C terminus of fragment	462	1081	298	119
Pfam domain	PF00104 (Hormone_recep)	PB064381	PF00069 (Pkinase)	PF02234 (CDI)
Best match PDB entry
PDB ID	1LBD	-	1V1K_A	-
presence of pockets	yes	-	yes	-
Similarity score for GO-term assignment
S_i^C	98*		98*
S_i^F	35**		31**
S_i^P	164**		60*

Statistical significance of similarity scores for GO-term assignment; * P < 0.05, ** P < 0.01.