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Table 4 Two promising candidates for drug-targetable PPIs

From: An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome data

  bait prey bait prey
protein name RXRA NRIP1 CDK2 CDKN1A
full length of amino acid sequence 462 1158 298 191
   N terminus of fragment 212 641 5 1
   C terminus of fragment 462 1081 298 119
Pfam domain PF00104 (Hormone_recep) PB064381 PF00069 (Pkinase) PF02234 (CDI)
Best match PDB entry     
   PDB ID 1LBD - 1V1K_A -
   presence of pockets yes - yes -
Similarity score for GO-term assignment     
   S i C 98* 98*
   S i F 35** 31**
   S i P 164** 60*
  1. Statistical significance of similarity scores for GO-term assignment; * P < 0.05, ** P < 0.01.
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BMC Pharmacology

ISSN: 1471-2210