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Figure 10 | BMC Pharmacology

Figure 10

From: A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones

Figure 10

Representative sensorgrams showing poly-APS binding to sphingomyelin/cholesterol (1/1) LUVs. 100 μl of poly-APS, dissolved in 140 mM NaCl, 20 mM Tris.HCl, 1 mM EDTA, pH 8.0, were injected at 30 μl/min for 3.3 min over the LUVs coupled to a Sensor Chip L1 at 25°C. Poly-APS were applied in the following order: 0.005 (A), 0.005 (B), 0.5 (C), and 0.5 (D) μg/ml. Inset: Sensorgrams showing the binding signal (A) of 0.5 μg/ml poly-APS applied over the freshly deposited sphingomyelin/cholesterol (1/1) LUVs, and (B) the binding signal to the same LUVs after 6 successive injections of poly-APS (0.5 μg/ml). The SPR experiments were run in triplicate.

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BMC Pharmacology

ISSN: 1471-2210