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Table 2 Potency (EC50) values of endogenous and modified CGRP ligands to generate cAMP in transiently transfected HEK293T-RAMP1 cells (in nM).

From: Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding

Peptide Agonist

Wild Type

L24A

L34A

L24A,L34A

CGRP

1.6 ± 0.1

1.5 ± 0.4

2.0 ± 0.5

1.3 ± 0.2

CGRP(1–36)

4300 ± 800

3400 ± 700

5600 ± 800

4200 ± 1900

CGRP(1–19)

2100 ± 600

2400 ± 200

2200 ± 600

1600 ± 200