From: Identification of specific calcitonin-like receptor residues important for calcitonin gene-related peptide high affinity binding
Peptide Agonist
Wild Type
L24A
L34A
L24A,L34A
CGRP
1.6 ± 0.1
1.5 ± 0.4
2.0 ± 0.5
1.3 ± 0.2
CGRP(1–36)
4300 ± 800
3400 ± 700
5600 ± 800
4200 ± 1900
CGRP(1–19)
2100 ± 600
2400 ± 200
2200 ± 600
1600 ± 200