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Table 1 Endogenous polyamine and aminoglycoside-mediated inhibition of anthrax lethal factor activity-comparison with other proteases-(Mean ± SEM K i a p p MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqqGlbWsdaqhaaWcbaGaemyAaKgabaGaemyyaeMaemiCaaNaemiCaahaaaaa@336E@ or IC50 values)

From: Cationic polyamines inhibit anthrax lethal factor protease

  LF Bot MMP-9 Furin
Name K i a p p MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqqGlbWsdaqhaaWcbaGaemyAaKgabaGaemyyaeMaemiCaaNaemiCaahaaaaa@336E@ μM IC50 μM K i a p p MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqqGlbWsdaqhaaWcbaGaemyAaKgabaGaemyyaeMaemiCaaNaemiCaahaaaaa@336E@ μM K i a p p MathType@MTEF@5@5@+=feaafiart1ev1aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacH8akY=wiFfYdH8Gipec8Eeeu0xXdbba9frFj0=OqFfea0dXdd9vqai=hGuQ8kuc9pgc9s8qqaq=dirpe0xb9q8qiLsFr0=vr0=vr0dc8meaabaqaciaacaGaaeqabaqabeGadaaakeaacqqGlbWsdaqhaaWcbaGaemyAaKgabaGaemyyaeMaemiCaaNaemiCaahaaaaa@336E@ μM
Neomycin B tris-sulfate 0.71 ± 0.04 92.5 >300 N/T
Sisomicin Sulfate 1.8 >300 >300 N/T
Spermine, diphosphate salt 0.9 ± 0.09 57 >300 N/T
Amikacin 23.3 >300 >300 N/T
Neamine (free base) 31.1 ± 5.6 175 >300 N/T
Spermidine >100 76 N/T N/T
Apramycin 111 >300 >300 N/T
Putrescine (1,4-diaminobutane) >300 >300 >300 N/T
Ac-CRATKML-N >300 3.5 N/T N/T
GM 6001 7.2 ± 1.76 >300 0.002 ± 0.001 N/T
H-RRRRRR-OH 0.24 N/T* N/T 0.06
Ac-RRRRRR-OH 0.29 ± 0.04 N/T N/T 0.05
Ac-RRRRRR-NH2 0.12 N/T N/T N/T
H-(D-Arg)-(D-Arg)-(D-Arg)-(D-Arg)-(D-Arg)-(D-Arg)-NH2 0.04 ± 0.02 N/T N/T 0.06
H-R(NO2)R(NO2) >300 N/T N/T N/T
Neomycin B hexaguanyl hexatrifluoroacetate salt 0.03 14 >170 1.5
Tetraguanyl neamine, free base 0.3 N/T N/T N/T
  1. *N/T = not tested