Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs

BMC Pharmacology

Table 1 Comparison of the K_I values of 5 psychostimulants to inhibit human and mouse monoamine transporters.

Drug	Cocaine	Methylphenidate	Amphetamine	Methamphetamine	MDMA
Human
hDAT	0.23 ± 0.03	0.06 ± 0.01	0.64 ± 0.14	0.46 ± 0.06	8.29 ± 1.67
hNET	0.48 ± 0.05	0.10 ± 0.01	0.07 ± 0.01	0.11 ± 0.01	1.19 ± 0.13
hSERT	0.74 ± 0.03	132.43 ± 10.71	38.46 ± 3.84	31.74 ± 2.40	2.41 ± 0.73
Ratio ¹	3.2	2207	549	288	7.0
Mouse
mDAT	0.49 ± 0.04 ²	0.26 ± 0.03	0.56 ± 0.11	0.47 ± 0.08	4.87 ± 0.65
mNET	0.46 ± 0.06 ²	0.17 ± 0.03	0.12 ± 0.02	0.19 ± 0.05	1.75 ± 0.51
mSERT	0.73 ± 0.12	114.37 ± 7.61	23.82 ± 1.71	9.28 ± 0.86	0.64 ± 0.05
Ratio ¹	1.6	672	199	49	7.6

The K_I values (in μM) were determined as illustrated in Fig. 1. They are expressed as mean ± S.E.M. of four to seven experiments. ¹ The ratios of highest K_I values over the lowest are shown to highlight the differences. ² The difference between these two K_I values was not statistically significant (ANOVA post hoc Bonferroni test, p > 0.05); all other values were statistically different (ANOVA comparing the three transporters within the same species and for the same drug).