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Figure 8 | BMC Pharmacology

Figure 8

From: Inhibition of p38 mitogen-activated protein kinase enhances c-Jun N-terminal kinase activity: Implication in inducible nitric oxide synthase expression

Figure 8

Effect of SB220025 on JNK activity. (A) Cells were stimulated with LPS 1 h before addition of SB220025. Incubations were terminated at the indicated time points and parallel immunoblots were run from same cell lysates using antibodies against Ser63 phosphorylated c-Jun (pc-Jun) and total c-Jun. Results are expressed as mean (n = 4). (B) Cells were stimulated with LPS 1 h before addition of tested compounds. Incubations were terminated 2 h after LPS and parallel immunoblots were run from same cell lysates using antibodies against Ser63 phosphorylated c-Jun (pc-Jun) and total c-Jun. Phosphorylated c-Jun values were normalised to total c-Jun values. Results are expressed as mean ± S.E.M (n = 3), *P < 0.05 compared with cells treated with LPS only.

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BMC Pharmacology

ISSN: 1471-2210