Skip to main content

Table 1 Effect of exogenous insulin administration on blood glucose (BG), serum insulin, C-peptide levels and small intestinal transit (SIT) in normal mice

From: Effect of insulin on small intestinal transit in normal mice is independent of blood glucose level

Treatment Insulin (U/kg;sc)a

Blood glucose levels

%SITe

Serum insulin levelsf (μU/ml)

Serum C-peptide levelsg (ng/ml)

 

Initial (mg/dL)b

Final (mg/dL)c

% Changed

   

Vehicle

70.66 ± 5.97

71.66 ± 5.93

101.96 ± 5.40

47.47 ± 3.22

32.62 ± 6.83

0.250 ± 0.01

2 μ

188.8 ± 29.73

198.8 ± 14.68

110.9 ± 10.65

68.43 ± 3.59**

55.18 ± 2.9

0.271 ± 0.01

2 m

128.16 ± 8.07

123.33 ± 13.62

94.88 ± 6.43

61.53 ± 4.42*

144.74 ± 13.43**

0.395 ± 0.02**

2

135.66 ± 8.76

53.66 ± 3.38

41.27 ± 5.60**

73.08 ± 2.18**

178.66 ± 12.23**

0.470 ± 0.01**

  1. Each value represents the mean ± SEM (n = 6)
  2. *P < 0.05; **P < 0.01 as compared with vehicle treated group
  3. a Insulin administered (s.c) 50 min before blood glucose/SIT estimation
  4. b Initial blood glucose levels were estimated before insulin/vehicle administration
  5. c Final blood glucose levels were estimated 50 min after insulin/vehicle administration (time coinciding with SIT determination)
  6. d % change (in blood glucose levels) obtained from any alteration in final BG value from initial BG level of each animal
  7. e Values are % SIT considering the total length of the intestine as 100, SIT was determined 50 min after insulin administration
  8. f Independent blood samples were collected at the time coinciding with SIT measurement for the measurement of serum insulin levels
  9. g Independent blood samples were collected at the time coinciding with SIT measurement for the measurement of C-peptide levels