TY - JOUR AU - Ward, Gregg R. AU - Abdel-Rahman, Abdel A. PY - 2006 DA - 2006/01/23 TI - Orchiectomy or androgen receptor blockade attenuates baroreflex-mediated bradycardia in conscious rats JO - BMC Pharmacology SP - 2 VL - 6 IS - 1 AB - Previous studies have shown that testosterone enhances baroreflex bradycardia. Therefore, conscious unrestrained rats were used to investigate the role of the androgen receptor in the testosterone-mediated modulation of baroreflex bradycardia. Androgen depletion (3 weeks), and androgen receptor blockade (20–24 h), were implemented to test the hypothesis that testosterone influences baroreflex bradycardia via its activity at the androgen receptor in male rats. Phenylephrine (1–16 μg kg-1) was used to assess baroreflex bradycardia. SN - 1471-2210 UR - https://doi.org/10.1186/1471-2210-6-2 DO - 10.1186/1471-2210-6-2 ID - Ward2006 ER -