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Table 1 Contractile responses to S6c and ET-1 in MCA incubated with four different PKC inhibitors

From: Inhibition of PKC activity blocks the increase of ETB receptor expression in cerebral arteries

   S6c   ET-1  
  n Emax (%) pEC50 Emax (%) pEC50
Control 10 131 ± 7 9.13 ± 0.10 152 ± 6 8.74 ± 0.12
Bisindolylmaleimide I 14 73 ± 8** 8.97 ± 0.08 143 ± 6 8.70 ± 0.08
Chelerythrine chloride 9 102 ± 7 8.95 ± 0.20 139 ± 6 8.77 ± 0.18
PKC inhibitor 20–28 14 67 ± 10** 8.80 ± 0.16 145 ± 7 8.64 ± 0.17
Ro-32-0432 9 6 ± 3*** 8.92 ± 0.07*** 194 ± 12 8.36 ± 0.09
  1. *P < 0.05, **P < 0.01, ***P < 0.001 compared to control. n represents the number of artery segments.