Table 1 Contractile responses to S6c and ET-1 in MCA incubated with four different PKC inhibitors
From: Inhibition of PKC activity blocks the increase of ETB receptor expression in cerebral arteries
S6c | ET-1 | ||||
|---|---|---|---|---|---|
n | Emax (%) | pEC50 | Emax (%) | pEC50 | |
Control | 10 | 131 ± 7 | 9.13 ± 0.10 | 152 ± 6 | 8.74 ± 0.12 |
Bisindolylmaleimide I | 14 | 73 ± 8** | 8.97 ± 0.08 | 143 ± 6 | 8.70 ± 0.08 |
Chelerythrine chloride | 9 | 102 ± 7 | 8.95 ± 0.20 | 139 ± 6 | 8.77 ± 0.18 |
PKC inhibitor 20–28 | 14 | 67 ± 10** | 8.80 ± 0.16 | 145 ± 7 | 8.64 ± 0.17 |
Ro-32-0432 | 9 | 6 ± 3*** | 8.92 ± 0.07*** | 194 ± 12 | 8.36 ± 0.09 |