Figure 4

Representative micrographs of histological sections (5 μm) of the knee joint: Panels A and B show damage of the articular cartilage lining the femur of a rat that was given a single dose of CFA (0.5 ml of 1 mg/ml) in the synovial cavity and daily oral dose (0.2 ml) of peanut oil for 28 days. A (Mag × 10), B (Mag × 20), scale bars = 20 μm, Arrows indicate areas of cartilage degradation. Panels C and D show the articular cartilage lining the femur of a rat that was given a single dose of CFA (0.5 ml of 1 mg/ml) in the synovial cavity and daily oral dose (6.2 mg/Kg) of 6-shogaol for 28 days. C (Mag × 10), D (Mag × 20), scale bars = 20 μm. Arrows indicate smooth articular cartilage surface and regular arrangement of chondrocytes in isogenous groups.