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Table 1 Characterization of recombinantly expressed human dopamine and h5HT2A receptors in HEK293 cell membrane preparations

From: Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis

 

Kd

Bmax

Kd Literaturea)

Receptor

nM

fmol/mg protein

nM

hD1

1.93 ± 0.24

3520 ± 790

0.35

hD2L

0.18 ± 0.02

1641 ± 462

0.06

hD3

0.84 ± 0.10

4060 ± 973

0.275

hD4.4

0.30 ± 0.06

493 ± 83.7

0.09

hD5

1.50 ± 0.23

1030 ± 263

0.30

h5HT2A

0.54 ± 0.07

165 ± 84.2

0.91

  1. a) Data taken from [14-17]
  2. [3H]SCH23390 was used for D1-like, [3H]spiperone for D2-like and 5HT2A receptors in homologous competition experiments. Data are mean ± SEM, n ≥ 3.
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