Figure 6
From: Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis
Functional analysis of the antagonist effect of LE404 at hD 1 and hD 2L receptors. The analysis was carried out by measuring the attenuation by LE404 of the agonist-induced increase in intracellular [Ca2+] in HEK293 cells recombinantly expressing hD1 and hD2L receptors, respectively. Dashed lines show 95% confidence intervals. SKF38393 was used as agonist at hD1 receptors, quinpirole at hD2L. All slopes were not significantly different from unity. Presented data are means ± SEM from at least three independent experiments each with at least threereplicates. A, B. Clark analysis of LE404 at hD1 (A) and hD2L receptors (B). Inserts show Clark plots.