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Figure 2 | BMC Pharmacology

Figure 2

From: Dibenzazecine compounds with a novel dopamine/5HT2A receptor profile and 3D-QSAR analysis

Figure 2

Buffer-dependent differences in hD 1 receptor potencies of LE300 in competition binding. Inhibition by LE300 of the binding of 0.2 nM [3H]SCH23390 to hD1 receptor expressing HEK293 cell membranes using Krebs-HEPES buffer pH 7.4 () or TRIS-HCl pH 7.4 (), respectively. Hill slopes were not different from unity. Nonspecific binding was determined with 1 μM SCH23390, and was less than 7%. Data shown are mean ± SEM, n = 3. Ki (Krebs-HEPES): 10.0 ± 1.15 nM; Ki (TRIS-HCl): 2.36 ± 0.13 nM.

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