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Figure 4 | BMC Pharmacology

Figure 4

From: A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones

Figure 4

Application of c.Sg or c.Lobo evoked a switch from single action potential firing to multiple firing in DRG neurones. A) Line graph showing that prior to application of c.Sg (100 μg/mL) only one action potential is evoked over a range of supramaximal stimuli (blue line). Application of c.Sg caused a reduction in threshold stimulus for action potential firing as well as a switch from single to multiple firing (red line). B) Similarly, c.Lobo (100 μg/mL) reduced the threshold for firing and converted a single firing DRG neurone (blue line) to a multiple firing neurone (red line). C) Current clamp traces illustrate the multiple firing behaviour of neurones that have been exposed to c.Sg. Also seen is the ability of c.Sg to reduce the threshold for firing. Furthermore, recovery is shown 45 minutes after the pressure ejecting c.Sg. In all cases the DRG neurones were held at -70 mV before stimulation.

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BMC Pharmacology

ISSN: 1471-2210