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Figure 11 | BMC Pharmacology

Figure 11

From: A pyridinium derivative from Red Sea soft corals inhibited voltage-activated potassium conductances and increased excitability of rat cultured sensory neurones

Figure 11

A purified sample from Sarcophyton glaucum (p.Sg) increased excitability and attenuated voltage-activated K+ currents in cultured DRG neurones. A) Example of voltage traces showing reversible inhibition of spike frequency adaptation and the development of multiple action potential firing by p.Sg (~10 μM). B) Voltage-clamp current traces showing the inhibitory effects of c.Sg (100 μg/mL) and p.Sg (30 μg/mL; ~200 μM) on DRG neurones held at -70 mV and depolarized to +60 mV by voltage step commands. Partial recovery of the net K+ current was seen after 10 mins. C) Line graph showing the current-voltage relationships under control conditions (blue line), after application of p.Sg (30 μg/mL; ~200 μM; green line) and then c.Sg (100 μg/mL; red line) recorded from a single DRG neurone.

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BMC Pharmacology

ISSN: 1471-2210