Figure 3
Sensitivities to the anesthetic etomidate. Modulation of GABA-induced currents by etomidate in recombinant GABAA receptors expressed in Xenopus oocytes. A. Representative traces of etomidate (Etom, μM) modulation of GABA-induced currents (G, EC25 in μM) in different receptor subtypes. Also the effect of flurazepam at 100 μM is shown for the α3β1γ2 receptors. B. Etomidate dose-response curves in the presence of EC25 GABA (set to 100 %). The values are means ± standard errors (n = 6 for α3β1; n = 7 for α3β1γ2; n = 9 for α3β1θ; n = 11 for α3β1ε and n = 4 for α3β1θε receptors).