Figure 1From: Phosphodiestrase 5 and effects of sildenafil on cerebral arteries from man and guinea pigConcentration-response curve for UK-90,234 (square), UK-114,542 (circle) and sildenafil (triangle) without (filled symbols) and with (open symbols) pre-treatment with the inhibitor of soluble guanylate cyclase, ODQ (10 μM), in intact arteries. Relaxation is given as % relaxation of pre-contraction and each point shows mean ± S.E.M. In high concentrations all compounds elicited a small cGMP-independent dilatory response.Back to article page