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Table 1 Toxicity of fatty acids or araC alone and in combination on normal (4D/WT) and transformed (D/v-src) rat colonic epithelial cells1

From: Low dose docosahexaenoic acid protects normal colonic epithelial cells from araC toxicity

 

DHA (n = 3)

AA (n = 3)

AraC (n = 3)

AA-araC (n = 3)

DHA-araC (n = 4)

 

IC50 μM

4D/WT cells

87.8 ± 10.2

91.1 ± 18.4

67.4 ± 11.1

9.3 ± 1.4

39.1 ± 10.4

D/v-src cells

14.9 ± 5.9*

12.2 ± 5.0*

41.8 ± 2.8

1.0 ± 0.6

1.3 ± 0.5*

  1. 1For the drug and fatty acid toxicity assays, cells were cultured in media supplemented with graded concentrations of araC or the fatty acids for 24 hrs. For the fatty acid supplemented drug toxicity assays, cells were treated with 3 μM DHA or AA for 24 hrs. Cells were then cultured in media supplemented with DHA or AA and graded concentrations of araC for an additional 24 hrs. Values are means ± SEM with sample sizes indicated in parenthesis. Values followed by * are significantly different from the values within the same column (p < 0.05).
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BMC Pharmacology

ISSN: 1471-2210