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Table 3 The fitted primary cardiovascular parameters for Magnesium data set 1 Units are as for Table 2. The parameter estimates are given with the standard deviation returned by the curve-fitting program. S1 could not be reliably fitted to the data.

From: Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of drugs – method development and application to magnesium in sheep

 

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Fitted parameter

(baseline)

estimate (sd)

estimate (sd)

estimate (sd)

estimate (sd)

estimate (sd)

MSC

n/a

3.88

2.96

4.75

1.67

4.74

CPLv

0.45

0.490 (0.0028)

0.495 (0.0075)

0.497 (0.0019)

0.505 (0.0049)

0.492 (0.0007)

SVR

17

11.99 (0.12)

9.84 (0.26)

11.84 (0.084)

14.64 (0.27)

16.74 (0.077)

CNT

3000

2988 (41)

3031 (104)

3388 (32)

3108 (80)

3180 (23)

S2

1

0.978 (0.023)

0.972 (0.055)

0.877 (0.014)

1.22 (0.06)

1.25 (0.017)