Skip to main content

Table 2 Distribution of laboratory data for patients included in the population pharmacokinetic analysis

From: Application of population pharmacokinetics to cladribine

 

Mean

SD

Range

Outliers

Creatinine clearance (mL/min)

81

27

5–162

5i, 16i, 27i, 161sc, 162i, o

S-aspartate aminotransferase (μkat/L)

0.52

0.44

0.07–4.4

1.9i, 2.1sc, 2.2i, 4.4i

S-alanine amintransferase (μkat/L)

0.49

0.5

0.08–5.3

1.6i, 2.0i, 2.1sc, 5.3i

S-alkaline phosphatase (μkat/L)

1.3

6.7

1.0–64

12i, 12i, 14sc, 54i, 64i

S-bilirubin (μmol/L)

14

25

3.0–284

41sc, 88i, 284i

  1. Outliers were defined as: Creatinine clearance <30->150 (mL/min), aspartate aminotransferase >1.5 (μkat/L), alanine amintransferase >1.5 (μkat/L), alkaline phosphatase >10 (μkat/L), bilirubin >30 (μmol/L)
  2. Abbreviations:i, infusion; o, oral; sc, subcutaneous