Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys

Table 1 Effect of CMN on cyclosporine-induced nephrotoxicity

Variables	Control	CsA (20)	CMN(15)	CsA (20)+ CMN(5)	CsA (20)+ CMN(10)	CsA (20)+ CMN(15)
Serum creatinine (mg/dl)	0.95 ± 0.01	3.12 ± 0.17^a	0.87 ± 0.01^b	2.00 ± 0.11^a,b	1.5 ± 0.06^a,b	1.00 ± 0.01^a,b
Creatinine clearance (ml/min)	0.76 ± 0.06	0.078 ± 0.05^a	0.87 ± 0.05^b	0.44 ± 0.03^a,b	0.65 ± 0.04^a,b	0.80 ± 0.05^b
BUN (mg/dl)	24.55 ± 0.77	87.44 ± 4.37^a	26.87 ± 0.64^b	73.65 ± 1.32^a,b	53.21 ± 0.9^a,b	35.89 ± 0.64 ^a,b
Urea clearance (ml/min)	0.58 ± 0.04	0.19 ± 0.05^a	0.61 ± 0.03^b	0.49 ± 0.02^a,b	0.53 ± 0.03^a,b	0.59 ± 0.03^b

Values are expressed mean ± mean. a = Statistical significant at P < 0.05 as compared to control, b = Statistical significant at P < 0.05 as compared to Cyclosporine (CsA)