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Table 1 Effect of CMN on cyclosporine-induced nephrotoxicity

From: Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys

Variables Control CsA (20) CMN(15) CsA (20)+ CMN(5) CsA (20)+ CMN(10) CsA (20)+ CMN(15)
Serum creatinine (mg/dl) 0.95 ± 0.01 3.12 ± 0.17a 0.87 ± 0.01b 2.00 ± 0.11a,b 1.5 ± 0.06a,b 1.00 ± 0.01a,b
Creatinine clearance (ml/min) 0.76 ± 0.06 0.078 ± 0.05a 0.87 ± 0.05b 0.44 ± 0.03a,b 0.65 ± 0.04a,b 0.80 ± 0.05b
BUN (mg/dl) 24.55 ± 0.77 87.44 ± 4.37a 26.87 ± 0.64b 73.65 ± 1.32a,b 53.21 ± 0.9a,b 35.89 ± 0.64 a,b
Urea clearance (ml/min) 0.58 ± 0.04 0.19 ± 0.05a 0.61 ± 0.03b 0.49 ± 0.02a,b 0.53 ± 0.03a,b 0.59 ± 0.03b
  1. Values are expressed mean ± mean. a = Statistical significant at P < 0.05 as compared to control, b = Statistical significant at P < 0.05 as compared to Cyclosporine (CsA)