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Table 3 Summary of results obtained after treatment with tolterodine and/or oxybutynin in the different models/conditions utilized.

From: Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions

Models/conditions Effect on BVC Effect on MP
Conscious rats – 1 day after surgery – i.v. and p.o. administration = ↓↓
Conscious (freely-moving/discontinuos cystometry) rats – 1 day after surgery – p.o. administration =
Conscious (cystometry at different rate of filling) rats – 1 day after surgery – p.o. administration =
Conscious (bladder infused with suramin) rats – 1 day after surgery – p.o. administration =
Conscious (bladder infused with acetic acid) rats – 1 day after surgery – p.o. administration = (↑) ↓↓
Conscious (obstructed) rats – 2 days after surgery – i.v. administration = n.e.
Conscious rats – 5 days after surgery – i.v. and p.o. administration =
Anesthetized rats – at the day of surgery – i.v. administration =
  1. = not significant change; ↓: decrease; ↓↓: dose-dependent decrease; n.e. = not evaluated (since the ligature around the urethra was not removed before cystometry, peak micturition pressure was not considered in these experiments); = (↑): some non dose-dependent effect was seen after tolterodine but not after oxybutynin.