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Table 1 Effect of intravenous administration of oxybutynin on cystometrographic parameters in anesthetized rats

From: Urodynamic effects of oxybutynin and tolterodine in conscious and anesthetized rats under different cystometrographic conditions

 

BVC (ml)

TP (mmHg)

MP (mmHg)

HFO (number)

HFO (amplitude)

Controls

     

Before

0.47 ± 0.04

4.74 ± 0.55

25.0 ± 3.6

4.2 ± 0.2

1.82 ± 0.19

After

0.47 ± 0.04

4.88 ± 0.58

20.9 ± 2.0

4.6 ± 0.2

1.63 ± 0.11

Oxybutynin 0.3 mg/kg

     

Before

0.44 ± 0.11

3.44 ± 0.84

20.3 ± 2.3

4.6 ± 0.2

1.68 ± 0.27

After

0.27 ± 0.05

2.34 ± 0.51

15.5 ± 1.7 **

4.2 ± 0.7

1.63 ± 0.24

  1. Data are expressed as mean ± s.e. mean. BVC: bladder volume capacity; TP: threshold pressure; MP: micturition pressure; HFO: high frequency oscillations (number and amplitude). * = p < 0.05; ** = p < 0.01 before vs after administration (Student's t test).
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BMC Pharmacology

ISSN: 1471-2210