Time-course of the effect of oral administration of oxybutynin and tolterodine on BVC and MP in conscious rats. Data represent the mean (± S.E.) of BVC (ml) and MP (mmHg) values recorded before treatment (0 min) and at different times after administration of: upper panel – vehicle (2 ml/kg; circles; n = 7) or oxybutynin (3 mg/kg; squares; n = 7); lower panel – vehicle (2 ml/kg; circles; n = 7) or tolterodine (10 mg/kg; squares n = 8). Rats were utilized 1 day after catheter implantation. Statistical analysis indicates significativity vs vehicle-treated group at considered times.