Effect of i.v. administration of tolterodine and oxybutynin on BVC and MP in conscious rats. Data represent the mean (± S.E.) AUC change of BVC and MP calculated as reported in the Method Section. Tolterodine was administered at 0.03 (n = 8), 0.1 (n = 9) and 0.3 (n = 8) mg/kg; oxybutynin at 0.1 (n = 5) and 0.3 (n = 8) mg/kg. Corresponding open bars represent changes recorded in the vehicle groups (n = 7). Rats were utilized 1 day after catheter implantation. Statistical significance was evaluated by ANOVA (and Dunnett's test).