Figure 10

Effect of i.v. administration of tolterodine and oxybutynin on BVC and MP in conscious rats with bladder infused with diluted acetic acid. Data represent the mean (± S.E.) AUC change of BVC and MP calculated as reported in the Method Section (basal values were those recorded at the end of the first hr of acid infusion). Tolterodine was administered at 0.03 (n = 7), 0.1 (n = 6) and 0.3 (n = 8) mg/kg; oxybutynin at 0.1 (n = 8) and 0.3 (n = 8) mg/kg. Corresponding open bars represent changes recorded in the vehicle groups (n = 7). Rats were utilized 1 day after catheter implantation. Statistical significance was evaluated by ANOVA (and Dunnett's test) or Student's t test.