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Figure 2 | BMC Pharmacology

Figure 2

From: In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine

Figure 2

Inhibition of oxotremorine-induced tremors with phenylephrine pretreatment. Male ICR mice (30–35 g) were treated with a single i.p. injection of phenylephrine hydrochloride (10 mg/kg; 10 μL/g). Each mouse was then placed in an individual shoebox cage for observation. Five minutes after this, each mouse was given a second i.p. injection of either vehicle (control; 10 μL/g) or desloratadine (free base) at a dose of 1.0 mg/kg (DL). Fifteen minutes later, each mouse received a single s.c. injection of oxotremorine sesquifumarate (0.5 mg/kg) at the nape of the neck. At 5, 10 and 15 minutes following the oxotremorine injection, mice were observed for severity of tremor and for the presence of salivation and lacrimation. The sum of the scores for the three time points is presented as Total Tremor Score. Numbers in parenthesis represent the number of animals in each group and asterisk denotes statistical significance (P < 0.05) vs. control.

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