Figure 1
From: In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine
Inhibition of oxotremorine-induced tremors. Mice were treated with a single i.p. injection of one of the test agents (atropine sulfate, AT; atropine methyl nitrate, AMN; diphenhydramine, DPH; methoctramine, MOT; 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide, 4-DAMP; desloratadine, DL) and placed in individual shoebox cages for observation. Fifteen minutes later, each mouse received a single s.c. injection of oxotremorine sesquifumarate (0.5 mg/kg) at the nape of the neck. At 5, 10 and 15 minutes following the oxotremorine injection, mice were observed for severity of tremor and for the presence of salivation and lacrimation. The sum of the scores for the three time points for tremor is presented as Total Tremor Score. Numbers in parenthesis represent the number of animals in each group and asterisk denotes statistical significance (P < 0.05) vs. control.