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Table 3 Dose- response relations between anti-cancer drugs for cytotoxic effect against human leukemia cell line HL-60 for 24 h; * P < 0.01; n = 3;

From: Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines

Compounds

Concentrations

OD values Mean ± SD

Percentage inhibition %

Control

--

1.229 ± 0.125

--

Probimane

10.0

0.298 ± 0.010*

75.6

 

2.0

0.260 ± 0.005*

78.9

 

0.4

1.142 ± 0.010

7.1

 

0.08

1.199 ± 0.012

2.4

Doxorubicin

10.0

0.256 ± 0.021*

79.2

 

2.0

0.266 ± 0.013*

78.3

 

0.4

0.312 ± 0.016*

74.5

 

0.08

0.408 ± 0.031*

66.9

5-Fluorouracil

5.0

0.421 ± 0.021*

65.6

 

1.0

0.518 ± 0.012*

57.9

 

0.2

0.585 ± 0.025*

54.4

 

0.04

0.892 ± 0.038*

27.5

Vincristine

5.0

0.425 ± 0.010*

65.4

 

1.0

0.423 ± 0.009*

65.6

 

0.2

0.401 ± 0.009*

67.4

 

0.04

0.394 ± 0.012*

68.0