TY - JOUR AU - Galmarini, Carlos MarĂ­a AU - Clarke, Marilyn L. AU - Jordheim, Lars AU - Santos, Cheryl L. AU - Cros, Emeline AU - Mackey, John R. AU - Dumontet, Charles PY - 2004 DA - 2004/05/24 TI - Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene JO - BMC Pharmacology SP - 8 VL - 4 IS - 1 AB - Gemcitabine is an analogue of deoxycytidine with activity against several solid tumors. In order to elucidate the mechanisms by which tumor cells become resistant to gemcitabine, we developed the resistant subline RL-G from the human follicular lymphoma cell line RL-7 by prolonged exposure of parental cells to increasing concentrations of gemcitabine. SN - 1471-2210 UR - https://doi.org/10.1186/1471-2210-4-8 DO - 10.1186/1471-2210-4-8 ID - Galmarini2004 ER -