Figure 7

Schematic overview of the APF method. Step1: A comprehensive peptide library comprising 8000 peptides is constructed. 360 peptides are extracted at random from the comprehensive peptide library and placed in the Analysis library. In a similar manner, 40 peptides are placed in the Prediction library. Step2: The binding free energies of the peptides extracted at random in Step1 are calculated using AutoDock3.0. Step3: The APF score matrix derived from the Analysis library are constructed using equation [1]. Moreover, prediction capability is validated by the APF score matrix against the peptides in the Prediction library. Step4: An Enriched library is constructed according to the APF score derived from the APF score matrix.