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Figure 4 | BMC Pharmacology

Figure 4

From: Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment

Figure 4

Measurement of airway hyperreactivity to aerosolised methacholine and effect of budesonide treatment. Actively sensitised female and male mice were treated intranasally with vehicle and challenged with PBS (n = 8) or ovalbumin (n = 10) one hour later. Different groups of animals were intranasally treated with 0.3 mg/kg (n = 10) or 3 mg/kg (n = 10) of budesonide and challenged with ovalbumin one hour after. Airway hyperreactivity to aerosolised methacholine was measured 24 hours after the challenge using whole body plesthysmography. ED300 values for methacholine (panel B) were calculated from the dose-response display in panel A by log-linear interpolation. Data are expressed as mean ± standard error. * and # indicate significance against the vehicle-treated group and when comparing male and female mice, respectively.

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