Table 9 Antitumor activities of anticancer drugs on human tumor LAX-83 using subrenal capsule assay: Route: ip × 5 daily from the day after surgery. * P < 0.05, ** P < 0.001 (treatment vs vehicle control). Experiment was completed within 7 days. Tumor volume = 1/2 × width2 × length (using T-test)
From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Compounds | Dosage mg/kg/d | No mice | Body weight (g) | Tumor volume (mm3) | Inhibition% |
|---|---|---|---|---|---|
Control | --- | 16 | 20.9/22.5 | 29.7 ± 3.2 | -- |
Methotrexate | 1.5 | 12 | 21.2/21.9 | 27.4 ± 3.0 | 7.7 |
Cis-platin | 1.5 | 12 | 22.8/21.7 | 16.6 ± 2.6** | 44.1 |
5-fluoruoracil | 37.5 | 12 | 21.7/21.4 | 12.8 ± 2.6** | 57.5 |
Cyclophosphamide | 30.0 | 12 | 21.0/20.9 | 5.8 ± 2.3** | 80.5 |
Vincristine | 0.3 | 12 | 20.8/20.8 | 7.6 ± 2.2** | 74.4 |