Table 8 Antitumor activities of Pro and Raz on human tumor LAX-83 using subrenal capsule assay: Route: ip × 5 daily from the day after surgery. * P < 0.05, ** P < 0.001 (treatment vs vehicle control). Experiment was completed within 7 days. Tumor volume = 1/2 × width2 × length (using T-test)
From: Antitumor effects of two bisdioxopiperazines against two experimental lung cancer models in vivo
Compounds | Dosage mg/kg/d | No mice | Body weight (g) | Tumor volume (mm3) | Inhibition% |
|---|---|---|---|---|---|
Control | --- | 16 | 19.2/21.0 | 39.8 ± 3.2 | -- |
Razoxane | 40 | 12 | 20.8/21.5 | 29.7 ± 3.0* | 25 |
Razoxane | 60 | 12 | 19.8/18.8 | 27.2 ± 2.8* | 32 |
Probimane | 80 | 12 | 20.0/19.6 | 18.0 ± 2.6** | 55 |
Probimane | 100 | 12 | 20.0/20.0 | 15.8 ± 2.6** | 60 |
Cyclophosphamide | 40 | 12 | 21.0/20.9 | 6.4 ± 2.0** | 84 |